Shadows over Sol was first published by Tab Creations in 2015, well before Mothership (2018), the Expanse RPG (2018) or Free League's Alien RPG. It was by no means the first science fiction horror RPG, but it came a little before the current wave of RPGs that are either directly inspired by Alien or indirectly by movies inspired by Alien. It feels like it was either a little to early or a little to late to receive the acolades it deserves. A second edition is being kickstarted now, with a free quickstarter as a taster, so it's a good time to have a look ... I'm still on the fence about this one, but at ther very least, it deserves attention.
Going by the quickstarter, the setting hasn't changed much from the first edition: 200 years from now, humanity has a few footholds in the Sol system (on Mars, in the asteroid belt, on the Jupiter moons). Society is cyberpunk-ish, with corporate control and people identifying more with their online tribe than with any of the rudimentary national states. Unitech, one of the big, mean corporations is doing a lot of secret experiments to create bioweapons, which is one source of the horror element of the setting (though there's also things like mind-controlling alien microorganisms and malevolent AI). There isn't really a big, overarching mythology behind all of it, more the idea that if you're working out in the black, you'll run into something horrifying on a regular basis.